Unigen Corporation

Mesfin Yimam

Qi Jia

Ping Jiao

Lidia Alfaro Brownell

Young-Chul Lee

Mei-Feng Hong

Mi-Ran Kim

Eu-Jin Hyun

Jeong-Bum Nam

Mi-Sun Oh

Bo-Su Lee

Min Chu

Teresa Horm

Tae-Woo Kim

Ji-Hye Hwang

Hyun-Jin Kim

Brandon Corneliusen

Breanna Moore

Mei Feng Hong

Ji-Fu Zhao

Qian Zhang

Mi-Hye Park

Byong-Il Choi

Julie Tseng-Crank

Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least oneextract enriched for one or more prenylated flavonoids, at least oneextract enriched for one or more free-B-ring flavonoids, and at least oneextract enriched for one or more flavans.

Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof

Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least oneextract, at least oneextract, and at least oneextract. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least oneextract enriched for one or more lignans, including phenylpropanoids, dimers and polymers, at least oneextract enriched for one or more polysaccharides and triterpenoids, and at least oneextract enriched for one or more lignans and organic acids. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least oneextract, at least oneextract, and at least oneextract.

Compositions, methods, and medical compositions for treatment of and maintaining the health of the liver

The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.

Skin care compositions and methods of use thereof

Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least oneextract, at least onegel powder, and at least oneextract. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least oneextract enriched for at least one polymer or biopolymer, at least onegel powder enriched for at least one chromone, and at least oneextract enriched for at least one lignan and organic acid.

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

Compositions and methods for joint health

The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.

Compositions and methods for managing weight

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

Compositions and methods for managing or improving bone disorders, cartilage disorders, or both

The identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial &#x3b2;-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPAR&#x3b1;/RXR&#x3b1; liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

Chromones as therapeutic agents

Growing community of inventors

Tacoma, WA, United States of America

Mesfin Yimam