Hoechst Aktiengesellschaft

Cassella Aktiengesellschaft

Merten Schlingmann

Reinhold Keller

Joachim Thiem

Wolfram Fritsche-Lang

Ernst I Leupold

Karl-Heinz Keil

Dieter Wullbrandt

Hartmut Voelskow

Matthias Wiesner

Udo Scharf

Hans-Ullrich Hoppe

Fritz Engelhardt

Axel Walch

Klaus Kuhlein

Hans-Matthias Deger

Edgar Fischer

Raimund Franz

Ulrich Greiner

Gerd Fulling

Gert-Wolfhard Von Rymon Lipinski

Martin Platen

Wolfgang Treder

Franz-Josef Dany

Susanne Grabley

Adolf Heinz Linkies

Manfred Schneider

Walter Dursch

Rudiger Erckel

Wolfgang Holla

Hans P Kraemer

Gerhard Wohner

Michael Magerstadt

Klaus-Dieter Vorlop

Werner Gohla

Johann Then

Hubert Bader

Diether Ruppel

Matthias Kreuzer

Kurt Rosenbusch

Karl-Heinz Schonwalder

Laslo Vertesy

Gerhard Hess

Hans M Deger

Traudel Kachholz

Kerstin Steinke

Hebert Bader

Dieter Ulschneider

Knut Rapp

In the enzymatic stereoselective ester cleavages of 2-arylpropionate, the reaction rate of the hydrolyzing enzymes can be drastically increased if the vinyl ester of the 2-arylpropionate is employed as the substrate.

Vinyl 2-aryl-propionates

The invention relates to polymer conjugates which are reversibly precipitable from aqueous solution and are composed of a carrier polymer which is soluble in aqueous medium and of a catalytically active compound which is chemically bonded thereto. The invention also relates to a process for the preparation of polymer conjugates of this type, and to the use thereof in homogeneous catalysis, especially biocatalysis.

Reversibly precipitable, water-soluble polymer conjugates

Sucrosetricarboxylic acid can be prepared by oxidizing sucrose with oxygen, if desired in a mixture with inert gases, by means of a more effective catalyst than platinum/alumina. The product can be used in washing agents or as a food additive.

Sucrosetricarboxylic acid and compositions containing the same

Process for the enzymatic cleavage of vinyl 2-aryl-propionates

A cofactor having an aromatic or benzylic amino group is converted into an isothiocyanate by reaction with a compound such as thiophosgene and the isothiocyanate of the cofactor is attached to a polymer which is preferably water-soluble. When the polymer has amino groups, a thiourea bridge is formed between the polymer and cofactor and a polymer having hydroxyl groups results in a thiocarbamate bridge. The polymer may be a copolymer of vinylamine or vinylmethylamine and vinylmethylacetamide, partially alkylamine-substituted .alpha., .beta.-poly-(2-hydroxyethyl)-D,L-aspartamide, polyethyleneimine or carbohydrate. The cofactor bound to a polymer and an enzyme are contained in microcapsules or in a membrane to form an enzyme reactor.

Immobilization of an isethiacyanate of a cofactor on a polymer

Polyelectrolyte membrane capsules are composed of a semi-permeable membrane and an active material enclosed by it, the membrane being formed of a biocompatible, non-toxic polyacid and a polybase; the polybase is composed of repeating monomer units of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 have the indicated meanings.

Microencapsulation of biologically active material

A process for the preparation of a mixture of sucrose oxidation products which contains a salt of sucrosetricarboxylic acid and which is obtained by reaction of sucrose with oxygen in an aqueous medium in the presence of a platinum metal/active carbon catalyst at elevated temperatures and neutralization of the reaction product to convert into the salt form, which comprises the reaction being carried out discontinuously, the starting materials being heated stepwise over the course of several hours from room temperature up to 60.degree. to 95.degree. C. and then the reaction product being isolated where appropriate. The oxidation products obtained in this way have, in particular, improved washing properties.

Process for the preparation of a mixture of sucrose oxidation products

Disaccharide fluorides can be prepared by incubation of .alpha.-D-glycosyl fluorides in concentrated solutions with .alpha.-glycosidases.

Process for the enzymatic preparation of disaccharide fluorides using

Resolution of the racemates of phosphorus-containing functional acetic acid derivatives can be carried out in high yield and in enantiomeric purity using hydrolases such as esterases and lipases.

Process for the enzymatic preparation of optically active phosphorus

A process for the oxidation of 5-hydroxymethylfurfural which comprises oxidizing 5-hydroxymethylfurfural in an aqueous medium with oxygen in the presence of a catalyst which contains at least one metal of the platinum group.

Process for the oxidation of 5-hydroxymethylfurfural

Dipeptide alkyl esters whose alkyl group contains 3 to 7 carbon atoms can be converted to the corresponding methyl ester compound by a rapid, gentle transesterification in anhydrous methanol in the presence of an alkali metal alcoholate, without racemization occuring on the two chiral carbon atoms.

Process for the preparation of aspartame and agents for carrying it out

.alpha.-Glucosyl fluoride can be converted in the presence of cyclodextrin .alpha.(1.fwdarw.4)glucosyltransferase into a mixture of .alpha.- and .beta.-cyclodextrins in high yield.

Enzymatic synthesis of cyclodextrins using .alpha.-glucosyl fluoride as

Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.

Diels-alder adduct from streptazoline and naphthoquinones and its

A process for the single-stage preparation of glycosyl fluorides by dissolving saccharides in liquid hydrogen fluoride and evaporating the hydrogen fluoride, wherein the resulting glycosyl fluoride is isolated in such a way that, when the evaporation of the hydrogen fluoride is started at a relatively high temperature, in general at -20.degree. to +20.degree. C., the evaporation is effected at a high evaporation rate or, when a low evaporation rate is used at the start of the evaporation, a sufficiently low temperature is set, in general -80.degree. C. to -30.degree. C.

Process for the single-stage preparation of glycosyl fluorides

Optically active enantiomers of alkyl .alpha.-phenoxypropionates, and of derivatives thereof, can be racemized in good yields and without formation of decomposition products with the aid of an alkali metal (C.sub.1 -C.sub.5) alcoholate, an alkali metal hydroquinone, an alkali metal phenolate or an alkali metal hydroxyphenoxypropionate, or derivatives thereof.

Process for racemizing optically active alpha-phenoxypropionic acid and

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Konigstein, Germany

Merten Schlingmann