Ciba-geigy Corporation

Merrill S Goldenberg

Karl F Mueller

Kai C Su

J Richard Robertson, Jr

Ellen Rennwantz

The crosslinked polymerization product of the reaction product of a polymeric backbone containing pendant hydroxyl groups with an unsaturated monoisocyanate or of said reaction product with an ethylenically unsaturated monomer gives a hydrogel material suitable for making contact lenses.

Crosslinked hydrogels derived from hydrophilic polymer backbones

The instant invention relates to vinylic macromers containing perfluoropolyalkylether and polyalklether segments, polymers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Vinylic macromers containing perfluoropolyalkylether and polyalkylether

Contact lenses which are optically clear, wettable, flexible, and of high oxygen permeability in the aqueous ocular environment of use, of a block copolymer containing polysiloxane and polyoxyalkylene oxide units are disclosed, as well as the preparation thereof and methods of treating vision defects therewith.

Wettable, flexible, oxygen permeable contact lens containing block

The instant invention relates to crosslinked copolymers of (a) vinylic macromers containing perfluoropolyalkylether and polyalkylether segments with (b) minor amounts of vinylic comonomers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Crosslinked copolymers and ophthalmic devices amde from vinylic

The instant invention relates to vinylic macromers containing perfluoropolyalkylether and polyalkylether segments, polymers and ophthalmic devices such as intraocular implants and contact lenses and particularly soft hydrogel contact lenses made therefrom.

Vinylic macromers containing perfluoropolyalkyl ether and polyalkyl

A contact lens of a crosslinked, organic aprotic solvent insoluble, substantially transparent polymer of a derivative of a polyvinyl alcohol having a weight average molecular weight of at least about 2,000, containing an effective amount between about 0.1 to 90 percent, based on the number of hydroxyl groups on said polyvinyl alcohol, of a crosslinked addition reaction product of units of the formula ##STR1## in the presence or absence of a polymerizable vinylic monomer wherein

Polyvinyl alcohol derivatives containing pendant vinylic monomer

Crosslinked copolymers and ophthalmic devices made from vinylic

A contact lens possessing a wettable surface in its aqueous environment of use fabricated from a hydrophobic addition polymer incorporating between about 0.5 and about 30% weight oxirane substituted units in the backbone thereof, wherein the outer surfaces of said lens contain an effective hydrophilic inducing amount of a reaction product of said oxirane substituted units of the formula ##STR1## wherein R is hydrogen or methyl;

Wettable surface modified contact lens fabricated from an oxirane

Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also --COOR.sub.5 where R.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.

Polyvinyl alcohol derivatives containing pendant (meth)acryloyl units

Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also -COOR.sub.5 where B.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.

Organic aprotic solvent insoluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of an addition reaction product of units of the formula ##STR1## with a vinylic monomer, wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also --COOR.sub.5 where R.sub.5 is hydrogen or lower alkyl, and hydrogel contact lenses made therefrom and their preparation.

Polyvinyl alcohol derivatives containing pendant (meth)acryloylvinylic

Optically clear soft contact lenses of a polyoxirane crosslinked polyvinyl alcohol having a weight average molecular weight of at least 8,000 and degree of hydrolysis of at least 93% and their preparation are disclosed. The materials are characterized by their ability to be boiling water sterilized, and their high water content, high oxygen permeability and high optical clarity.

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Teaneck, NJ, United States of America

Merrill S Goldenberg