Duke University

Other

W. L. Gore & Associates, Inc.

Merrill J Birdno

Warren M Grill

David T Brocker

Edward Emil Shaw

Serge Cyril Roux

Mark C Preul

Matthew DeNardo

Brandon C Short

Alireza Mashal

Linda Marie Donoghue

Matthew B Denardo

Brent Vernon

Mike A Schmieder

Franck J Rubiconi

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency. The systems and methods for stimulation of neurological tissue may be used to increase the efficacy of treatment in patients with Parkinson's Disease.

Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's disease

This disclosure relates generally to treatment programs utilizing expansion elements, such as those associated with occlusion and therapeutic agent delivery devices, systems, and methods. In some more specific examples, treatment programs include expansion-contraction cycles at a pre-selected frequency profile configured to treat a particular condition, such as calcification of an arterial conduit, for example.

Cyclic expansion tissue treatment programs and associated systems

Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.

Non-regular electrical stimulation patterns for treating neurological disorders

Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's Disease

A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.

In situ gelling self-reactive materials for embolization

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Flagstaff, AZ, United States of America

Merrill J Birdno