Beijing University of Technology

Murdoch University

The University of Western Australia

Merlin Christopher Thomas

Raelene Jane Pickering

Carlos Rosado

Stephen Donald Wilton

Kevin Donald George Pfleger

Christos Tikellis

A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.

Screening assays, modulators and modulation of activation of Receptor for Advanced Glycation End-products (RAGE)

An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

Modulators and modulation of the receptor for advanced glycation end-products RNA

Growing community of inventors

Clayton, Australia

Merlin Christopher Thomas