The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Massachusetts General Hospital Corporation

Metabolon, Inc.

Merit Cudkowicz

Howard L Weiner

Kay A Lawton

Matthew W Mitchell

Anne M Evans

Don Harvan

Robert Brown

Lisa A Paige

Oleg Butovsky

James Berry

Provided herein are methods of treating a neurodegenerative disorder such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS) that include administering to a subject at least one inhibitory nucleic acid that decreases the level or activity of microRNA hsa-miR-155.

Micrornas in neurodegenerative disorders

The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.

Biomarkers for amyotrophic lateral sclerosis and methods using the same

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Newton, MA, United States of America

Merit Cudkowicz