Novus International, Inc.

Mercedes Vazquez-Anon

Christopher D Knight

Lyle M Rode

Karen M Koenig

Michael J Vandenberg

Gavin R Bowman

Graciela Arhancet

Karen Joy Wedekind

Matthew Mahoney

Scott Long

Robert Harrell

Drew L Lichtenstein

Juxing Chen

Vivek Kuttappan

Andrew F Giesen

Jeffery Escobar Monestel

Steven Andrew Webb

James Richards

Junmei Zhao

Mariya Grega

Megharaja K Manangi

Graciela B Arhancet

The present invention relates to biomarkers that are associated with joint disorders, and methods of using the biomarkers diagnose joint ailments, monitor the progression of joint ailments, determine when treatments is indicated, and monitor the efficiency of treatment. Also provided are methods for treating joint ailments, which comprise administering chelated trace minerals to animals diagnosed with or predisposed to having joint ailments.

Biomarkers for joint ailments and uses thereof

Antimicrobial compositions comprising sulfur- or selenium-containing, fatty-acylated alpha-hydroxy acid compounds and methods of using said compounds or compositions to inhibit microbial growth.

Antimicrobial compositions and uses thereof

The present invention provides a combination of antioxidants that effectively stabilize different types of fats utilized in a ruminant diet. When included in a ruminant feed ration or water source, the antioxidant combination typically increases nutrient digestion, such as fiber and protein, improves rumen fermentation, improves microbial growth, improves microbial efficiency, increases milk production and/or milk fat, improves antioxidant status of the ruminant, and attenuates the negative effects of some fats in the ruminant animal.

Antioxidant combinations for use in ruminant feed rations

The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the combinations of the invention comprise antioxidants, trace minerals, organic acids, essential amino acids, and mixtures thereof.

Combinations to improve animal health and performance

Antioxidant combinations for use in feed rations to increase milk production and milk fat

A method for enhancing the palatability of aquaculture food, the method comprising treating the food with a compound of Formula I: wherein R, R, R, and n are as defined herein, are disclosed.

Palatability of aquaculture feed

A method of supplying a ruminant with its nutritional requirements for methionine is provided wherein a hydroxy analogue of methionine that is available for absorption by a ruminant is administered to the ruminant. Preferably, the, ruminant is administered an isopropyl ester of a hydroxy analogue of methionine, wherein at least 40% of the isopropyl ester of the hydroxy analogue of methionine is available for absorption by the cow.

Process for optimizing milk production

A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of said ingredients are identified wherein one of said ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.

A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of the ingredients are identified wherein one of the ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.

Growing community of inventors

Chesterfield, MO, United States of America

Mercedes Vazquez-Anon