Incube Labs, LLC

Rani Therapeutics, LLC

Mercedes Morales

Mir A Imran

Mir Hashim

Radhika Korupolu

Joel M Harris

Elaine To

Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins

Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-&#x3b1;-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.

Pharmaceutical compositions and methods for fabrication of solid masses comprising TNF-inhibiting antibodies

Shaped mass composition comprising exenatide

Pharmaceutical compositions and methods for fabrication of solid masses comprising anti-interleukin antibodies

Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins

Pharmaceutical compositions and methods for fabrication of solid masses comprising immunoglobulins

Growing community of inventors

San Jose, CA, United States of America

Mercedes Morales