Colorado State University Research Foundation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Creighton University

Mercedes Gonzalez-Juarrero

Nadya Tarasova

Mary C Jackson

E Jeffrey North

Amitkumar Navinchandra Pandya

Wei Li

The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.

Chemical probes to identify anti-mycobacterial MmpL3 inhibitors

The invention provides a method of treating pathogenic bacterial infection (e.g., tuberculosis infection) in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal. The invention also provides methods of treating chronic granulomatous disease and Wegener's granulomatosis in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal.

Use of peptide-based inhibitors of the stat3-IL10 pathway for treating bacterial infection and granulomatous disease

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Fort Collins, CO, United States of America

Mercedes Gonzalez-Juarrero