Pharma Mar, S.a.

Universidad De Barcelona

Mercedes Alvarez

Lidia Feliu

Jose Luis Fernandez-Puentes

David Ferández Bleda

José Luis Fernández Puentes

Dolores Garcia Gravalos

The invention provides antitumour compounds of formula (I), wherein Ris an aromatic substituent; Ris hydrogen or a substituent when the dotted line is absent, or Ris absent when the dotted line represents a bond to give a double bond between the nitrogen which bears Rand the carbon which bears R; Ris an oxo group &#x2550;O when the dotted line is absent or is a substituent when the dotted line represents a bond to give a double bond between the nitrogen bearing Rand the carbon bearing R; Ris hydrogen or a substituent; and pharmaceutically acceptable salts thereof.

Derivatives of variolin B

Cytotoxic pyrido&lsqb;2,3,4-ki&rsqb;acridine derivatives, their preparation and their therapeutic use

Growing community of inventors

Barcelona, Spain

Mercedes Alvarez