Merck Patent Gmbh

Mengyao Zheng

Dieter Lubda

Nicole Di Gallo

Alessandro Elia

Anja-Nadine Knuettel

The present invention relates to the use of spray-dried sorbitol, such as Parteck&#xae; SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.

Hot melt extrusion composition using direct compressible excipient as plasticizer

An extrudable polyvinyl alcohol (PVA) powder with improved flowability containing particles of PVA, which has been cryo-milled, and which has dparticle sizes in the range of 45 to 1400 &#x3bc;m; or which has a particle size distribution of d=20&#xb1;10 &#x3bc;m, d=30&#xb1;10 &#x3bc;m, d=70&#xb1;10 &#x3bc;m, d=200&#xb1;30 &#x3bc;m, and d=300&#xb1;30 &#x3bc;m; and a powdery composition for the preparation of pharmaceutical formulations which contains the polyvinyl alcohol homogeneously mixed with at least one active pharmaceutical ingredient (API); and a process for producing a solid pharmaceutical dosage form by extruding or forming a homogeneous melt of a mixture of ingredients containing the powdered polyvinyl alcohol and at least one active pharmaceutical ingredient (API), and forming a powder or a molded form.

Particle size and distribution of polymer for melt extrusion application

The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular for compositions which are intensively mixed by treatment in a melt extrusion and then formulated by suitable post-treatment.

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Bensheim, Germany

Mengyao Zheng