Mimedx Group, Inc.

Drexel University

University of Pennsylvania

The Children's Hospital of Philadelphia

Mengyan Li

Thomas J Koob

Peter I Lelkes

Anat Perets

Daniel Hernandez

Philip Lazarovici

Kerriann Greenhalgh

Leon Paulos

Honesto Poblete

Robert J Levy

Frank K Ko

Mark J Mondrinos

Russell Composto

Pimporn Uttayarat

The disclosure describes implantable bioprosthesis and constructs having an implantable woven ribbon with at least one integrated suture.

Collagen fiber ribbons with integrated fixation sutures and methods of making the same

The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.

Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches

Medical constructs with collagen fibers and gelatin and related collagen fibers. The collagen fibers can be derived from extruded soluble dermal collagen and can include a gelatin film attached to the at least one collagen fiber. The gelatin film can include one or more minerals and has a gelatin concentration of between about 0.1% to about 40% weight per volume.

Medical constructs including tubes and collagen fibers

Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.

Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices

Methods of making collagen fiber medical constructs and related medical constructs, including tubes

The disclosure describes methods of making collagen based biocomposite constructs and related devices. The methods include: (a) winding at least one collagen fiber a number of revolutions about a length of a support member having a long axis, the winding having at least one defined pitch and/or fiber angle relative to the long axis of the support member to form an elongate construct; and (b) applying a fluid polymeric material, such as, for example, an acrylate emulsion and/or other thermoplastic material, onto the collagen fiber during the winding step. Optionally, the fluid polymeric material can include antibiotics and/or other therapeutic agents for additional function/utility.

Biocomposite medical constructs including artificial tissues, vessels and patches

The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.

Small diameter vascular graft produced by a hybrid method

Methods for making collagen based biocomposite constructs and related devices include: (a) winding at least one collagen fiber a number of revolutions about a length of a support member having a long axis, the winding having at least one defined pitch and/or fiber angle relative to the long axis of the support member to form an elongate construct; and (b) applying a fluid polymeric material, such as, for example, an acrylate emulsion and/or other thermoplastic material, onto the collagen fiber during the winding step. Optionally, the fluid polymeric material can include antibiotics and/or other therapeutic agents for additional function/utility.

Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches

Non-woven fibrous scaffolds made by electrospinning from the synthetic biodegradable polymer such as, for example, poly(lactic-co-glycolic acid) (PLGA) and natural proteins, such as, for example, gelatin (denatured collagen) and elastin and a method of making thereof.

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Tampa, FL, United States of America

Mengyan Li