Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Mengwei Huang

Lichun Feng

Li Chen

Yongfu Liu

Hongying Yun

Mingwei Zhou

Guolong Wu

Jim Zhen Wu

Lisha Wang

Chungen Liang

Xiufang Zheng

Lu Gao

Song Feng

Tao Guo

Yun He

Xihan Wu

Jason Christopher Wong

Wei Zhu

Jia Tao Li

Weixing Zhang

Fajun Nan

Lei Guo

Shixiang Yan

Baoxia Wang

Mei Zhang

Tao Pang

Lifang Yu

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto R, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.

Compounds for the treatment and prophylaxis of respiratory syncytial virus disease

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, R, W, W, W, A and X are as described herein, compositions including the compounds and methods of using the compounds for the treatment and prophylaxis of respiratory syncytial virus infection.

Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection

Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein Rto R, Ato Ahave the are as described herein and compositions including the compounds.

Tetrahydroquinoline derivatives

The present invention provides compounds of formula (I), as well as pharmaceutically acceptable salt thereof, wherein Rto Rhave the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases that are related to AMPK regulation.

Alkene oxindole derivatives

A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein Ato Aand Rto Rhave the significance given in claim, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

Tetrahydro-quinoline derivatives

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto Rhave the significance given in claim, can be used as a medicament.

3,3-dimethyl tetrahydroquinoline derivatives

The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein Rto Rhave the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto Rhave the significance given in claim. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes.

Cyclopropane indolinone derivatives

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Shanghai, China

Mengwei Huang