General Electric Company

Baker Hughes, a Ge Compnay, LLC

Mengli Wang

Kashan Ali Shaikh

Jessica Godin Karp

Ralf Lenigk

Christine Lynne Surrette

Xiaohui Chen

Christine Lynne Pitner

Adriana Ines Larriera Moreno

Ertugrul Berkcan

William Albert Challener

Lembit Salasoo

Xiaolei Shi

Naresh Sundaram Iyer

Subhrajit Roychowdhury

Roman Leon Artiuch

Cheng-Po Chen

Justin John Gambone, Jr

Vipul Kumar Gupta

Nannan Chen

Xiaohu Ping

Jr Justin Gambone

A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.

Erythrocyte aggregation and leukocyte isolation

Determining a quality score for a part manufactured by an additive manufacturing machine based on build parameters and sensor data without the need for extensive physical testing of the part. Sensor data is received from the additive manufacturing machine during manufacture of the part using a first set of build parameters. The first set of build parameters is received. A first algorithm is applied to the first set of build parameters and the received sensor data to generate a quality score. The first algorithm is trained by receiving a reference derived from physical measurements performed on at least one reference part built using a reference set of build parameters. The quality score is output via the communication interface of the device.

System and methods for determining a quality score for a part manufactured by an additive manufacturing machine

An accelerometer includes a membrane, an energy source producing a laser beam which is directed at the membrane causing it to vibrate, and a transparent cap disposed at one end of the energy source. The accelerometer includes a first controller for adjusting an output power of the energy source in a first feedback loop, a second controller for controlling the wavelength of the laser beam in a second feedback loop, and a detector sensing a reflected portion of the laser beam. An acceleration signal is based in part on the frequency of the reflected portion of the laser beam.

Optical accelerometers for use in navigation grade environments

A system for metering gas a fluid stream includes a primary conduit and a secondary conduit coupled to the primary conduit such that the secondary conduit receives a portion of a fluid stream passing through the primary conduit. A flow manager disposed in the primary conduit is configured to maintain a predetermined relationship between at least one first physical characteristic of the fluid stream and at least one second physical characteristic of the portion of the fluid stream. A sensor measures a flow characteristic of the portion of the fluid stream and a processor determines a flow parameter of the fluid stream based, at least in part, on the predetermined relationship and one of an amplitude or temporal characteristic of the electrical signal.

System and method for metering gas based on amplitude and/or temporal characteristics of an electrical signal

A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.

Microfluidic flow cell assemblies and method of use

A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.

Microfluidic flow cell assemblies for imaging and method of use

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Niskayuna, NY, United States of America

Mengli Wang