Industrial Technology Research Institute

Meng-Yow Hsieh

Hsin-Hsin Shen

Chin-Fu Chen

Tsai-Yu Lin

Yu-Bing Liou

Wei-Lin Yu

Pei-Shan Li

Miao-Tzu Chen

Yi-Hung Lin

Jui-Hsiang Chen

Yu-Chi Wang

Jui-Sheng Sun

Li-Hsin Lin

Ying-Hsueh Chao

Hsiu-Hua Huang

Jean-Dean Yang

Sen-Lu Chen

Po-Liang Lai

Chih-Bing Hung

Hsin-hsin Shen

Chih-Hung Chang

Liang-Yo Yang

Wen-Fu Lee

Shen-Hua Peng

Pei Pei Cheng

Kei-Hung Wu

The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2'-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

Hydrogel composition and method for using the same

The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

Solid form and method for preparing the same

Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II):A-B-BOX-B-A&#x2003;&#x2003;Formula (I)B-A-B-(BOX-B-A-B)-BOX-B-A-B&#x2003;&#x2003;Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2'-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.

Thermal responsive composition for treating bone diseases

Biodegradable copolymer hydrogels are provided. The biodegradable copolymer hydrogels have a structure of Formula (I) or Formula (II)A-B&#x2014;BOX&#x2014;B-A&#x2003;&#x2003;Formula (I)B-A-B&#x2014;(BOX&#x2014;B-A-B)-BOX&#x2014;B-A-B&#x2003;&#x2003;Formula (II),

Biodegradable copolymer hydrogels

An aliphatic polyester polymer compositions and preparation method thereof. The invention provides a bioresorbable aliphatic polyester copolymer, comprising the reaction product of a first polyester, a second polyester, and a coupling agent. Specifically, the first polyester and second polyester have the same repeat units, but different weight average molecular weights. Methods for preparing the aliphatic polyester copolymer are provided, in which the first polyester reacts with the second polyester in the presence of the coupling agent, undergoing copolymerization.

Aliphatic polyester polymer compositions and preparation method thereof

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Meng-Yow Hsieh