Roche Palo Alto LLC

Meng Sui

Shu-Hai Zhao

Nancy Elisabeth Krauss

Counde O'Yang

Hans Maag

Joe Timothy Bamberg

Compounds of formula I or formula II: or pharmaceutically acceptable salts thereof, wherein m, n, p, Ar R, R, R, and Rare as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds.

Indole and benzofuran 2-carboxamide derivatives and uses thereof

Compounds of the formula I: and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is &#x2014;(CRR)&#x2014;, A is &#x2014;NR, m is 2, n is 1, q is 2, Ris optioinally substituted aryl or optionally substituted heteroaryl, and p, R, R, R, R, R, R, R, R, and R, are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of central nervous system diseases.

Quinazolinone and benzoxazinone derivatives and uses thereof

Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is &#x2014;SO&#x2014; or &#x2014;(CRR)&#x2014;, n is 1 or 2, Ris aryl or heteroaryl, and R, R, R, R, R, R, R, R, R, R, m, p, q and r, are as defined herein. The compounds are modulators of the 5-HT6 receptor and are useful for treatment of central nervous system disorders. Also provided are methods for preparing, compositions comprising, and methods for using Compounds of Formula I.

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Union City, CA, United States of America

Meng Sui