National Cheng-Kung University

National Health Research Institutes

University of California

Meng-Ru Shen

Ming-Shi Chang

Wentai Liu

Jang-Yang Chang

Kak-Shan Shia

Chien-Huang Wu

Lian-Yun Chang

Yuan-Ting Sun

Yen-Chen Liu

Li-Hsien Chen

Ya-Ting Hsu

Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy-induced peripheral neuropathy.

Pyrimidine compounds and use thereof

A method for assessment of neural function by establishing an analysis module is revealed. The first step of the method is to capture images of the cultured cells with a plurality of fluorescence labeling by a fluorescence microscopy system for image analysis. The cultured cells include neurons and non-neuronal cells. Then select neurons with neurites having fluorescence labeling and exclude non-neuronal cells according to an area and a fluorescence intensity of nucleus. Also calculate an area of the neuronal cell body, a length of the neurites and a number of processes and branches to verify outgrowth of the neurites of the neurons. Next calculate a number of synaptic puncta having fluorescence labeling on the area of the neurites having fluorescence labeling defined in Step 2 to verify formation of the synaptic puncta of the neurons for assessment of neural function.

Method for assessment of neural function by establishing analysis module

Reducing inflammatory pain in a subject having or being suspected of having an inflammatory pain using an IL-20 antagonist, which can be an antibody that blocks a signaling pathway mediated by IL-20. Such antibodies include anti-IL-20 antibodies and anti-IL-20R antibodies that specifically block the IL-20 signaling pathway.

Treatment of inflammatory pain using IL-20 antagonists

Growing community of inventors

Tainan, Taiwan

Meng-Ru Shen