Reber Genetics Co., Ltd.

Gnt Biotech & Medicals Corporation

Meng-Ju Tsai

Hsiu-Kang Chang

Chia-Nan Chen

Wei-Jan Huang

Li-Ling Chi

Ye-Su Chao

Yi-Hong Wu

Wei-I Chou

Ching-Yi Lin

Yu-Jung Liao

Huan-Yu Lin

Yu-Hsin Chien

Wan-Yi Hsu

Pao-Yen Lai

Ching-yi Lin

The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

PH-sensitive linkers for delivering a therapeutic agent

A fusion protein comprising an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, a translocation peptide, a fusion antigen, an endoplasmic reticulum retention sequence, and optionally a nuclear export signal is disclosed. The fusion antigen comprises a porcine reproductive and respiratory syndrome virus (PRRSV) ORF7 antigen, a PRRSV ORF1b antigen, a PRRSV ORF6 antigen, and a PRRSV ORF5 antigen. The fusion protein is useful for inducing antigen-specific cell-mediated and humoral responses.

Vaccine compositions against porcine reproductive and respiratory syndrome and porcine circovirus associated diseases

Growing community of inventors

Taipei, Taiwan

Meng-Ju Tsai