Industrial Technology Research Institute

Chang Gung University

Chiayi Chang Gung Memorial Hospital

Meng-Huang Wu

Hsin-Hsin Shen

Chih-Chieh Huang

Pei-I Tsai

Sung-Ho Liu

Ching-Chih Lin

Ji-Bin Horng

Yi-Hung Wen

Hong-Jen Lai

Fang-Hei Tsau

Shih-Ping Lin

Ming-Jun Li

Fang-Chieh Chang

Chung-Sheng Shi

Kuo-Ti Peng

Jane S C Tsai

An artificial intervertebral disc is configured to be inserted between adjacent human vertebrae. The artificial intervertebral disc includes a first connection block, a joint block and a second connection block. The joint block has a convex surface and a rear surface. The rear surface of the joint block is stacked on the first connection block. The second connection block is slidably stacked on the convex surface of the joint block, such that the second connection block is movable relative to the first connection block. In addition, the convex surface is a curved surface, and the convex surface is arranged off-axis with respect to the rear surface.

Artificial intervertebral disc

Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises administering to the subject an effective amount of an inhibitor on inhibiting neddylation. According to some embodiments of the present disclosure, the inhibitor on inhibiting neddylation is a NAE inhibitor, which includes but is not limited to, MLN4924.

Method of preventing or treating osteoporosis by neddylation inhibitor

An implant device for osseous integration includes a plurality of connection bars and at least one frame bar. These connection bars are connected with each other to form a three-dimensional (3D) grid structure. The frame bar is connected with at least two of the connection bars to define at least one edge of the 3D grid structure. Wherein, the frame bar has a diameter substantially greater than that of these connection bars.

Implant device for osseous integration

Growing community of inventors

Taipei, Taiwan

Meng-Huang Wu