The General Hospital Corporation

Meng-Chen Lo

Alik S Widge

Emad N Eskandar

Darin D Dougherty

Ishita Basu

Ethan Blackwood

A method for controlling synchrony in a plurality of brain regions of a subject includes receiving signals from a source region of the subject's brain, determining at least one phase of the signals from the source region in a predetermined frequency band and delivering at least one stimulation pulse to at least one target region of the subjects brain based on the at least one phase of the signals from the source region to synchronize oscillations of the source region and the at least one target region.

Systems and methods for controlling synchrony in a plurality of brain regions

Systems and methods for controlling brain activity are provided. In some aspects, a method for controlling a synchrony in brain activity of a subject is provided. The method includes positioning stimulators to stimulate a first region and a second region of a subject's brain, and selecting a pulsed stimulation sequence comprising a first stimulation to the first region and a second stimulation to the second region, wherein the stimulations are timed to be substantially concurrent and separated by a phase lag. The method also includes delivering the pulsed stimulation sequence, using the stimulators, to control a synchrony between the first region and the second region at a predetermined frequency.

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Cambridge, MA, United States of America

Meng-Chen Lo