Yeda Research and Develpment & Co. Ltd

Other

University of Colorado

Merck Serono S. A.

Menachem Rubinstein

Daniela Novick

Charles A Dinarello

Soo Hyun Kim

David Wallach

Michel Revel

Hartmut Engelmann

Dina G Fischer

Dan Aderka

Batya Cohen

Nathan Tal

Yolande Chvatchko

Christine Plater-Zyberk

Ariel Werman

Ben Alkahe

Yves Mory

Louise Chen

Tsvee Lapidot

Tamir Tuller

Soo-Hyun Kim

Boris Schwartsburd

Alexander Kalinkovich

Leonid Reznikov

Vladimir Hurgin

Shoham Shivtiel

Jossef Friedlander

Yvez Mory

Giamila Fantuzzi

Dalit Barkan

Yitzhak Pilpel

Bianling Liu

Pierre Graber

Patricia Orchansky

Sivan Navon

Asaf Spiegel

Eran Hadas

Santer Van Deventer

Daniela Weizmann Institute Of Science Novick

Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.

Recombinant protein production in heterologous systems

The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.

Method for screening inhibitors of interleukin-32 (IL-32)

An invention relates to a glycan-modified soluble receptor or binding protein of a cytokine, growth factor, lipoprotein or oxidized lipoprotein, modified to carry a terminal Gal, GlcNAc or GalNAc.

Glycan modified soluble receptors and binding protein and their use

Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.

Antibodies against interleukin-18 binding protein, their preparation and use

The invention relates to the use of the souluble LDL receptor (sLDLR) in viral hepatitis.

Method for inhibiting release of hepatitis B virus from liver cells

The invention relates to receptors of catecholamines and their role in stem cell development and function.

Catecholamine receptor modulation

An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.

Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA

The present invention relates to the promoter of interleukin-18 binding protein (IL-18BP), to its preparation and use.

Promoter to IL-18BP, its preparation and use

Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.

Interleukin-18 binding proteins, their preparation and use

The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.

Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis

Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.

Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins

The invention provides a method for determining the presence of leptin in a sample.

Leptin assay

The use of leptin and leptin-related molecules in oncology is disclosed.

Leptin as an inhibitor of tumor cell proliferation

Growing community of inventors

Rehovot, Israel

Menachem Rubinstein