Xenon Pharmaceuticals Inc.

Agouron Pharmaceuticals, Inc.

Inspire Pharmaceuticals, Inc.

Sephoris Pharmaceuticals, LLC

Other

Abbott Laboratories Corporation

Syntex (u.s.a.) Inc.

Florengale, LLC

Melwyn A Abreo

Chi Tu

Shaoyi Sun

Serguei Sviridov

Rajender Kamboj

Shifeng Liu

Vishnumurthy Kodumuru

Michael D Winther

Heinz W Gschwend

Daniel F Harvey

Wenbao Li

Mark W Holladay

Zaihui Zhang

Sammy Ray Shaver

Steven Lee Bender

Nagasree Chakka

Vandna Raina

Robert Plourde, Jr

Lorenzo Josue Alfaro-Lopez

Tatyana V Khasonova

Talal Sheena

Maria Angelica Linton

Yangbo Feng

Mikhail Kondratenko

Jian Jeffrey Chen

Arlindo Lucas Castelhano

Judith Gail Deal

José L Boyer

Sultan Chowdhury

Mikhail A Chafeev

Jian-Min Fu

Paul Steven Watson

Roland Joseph Billedeau

James G Douglass, Iii

Duanjie Hou

Mehran Seid Bagherzadeh

Sengen Sun

Wesley K M Chong

Cindy J Hudson

Nan-Horng Lin

David E Gunn, Jr

David S Garvey

Peter Scott Dragovich

Yun He

John Howard Tatlock

Allen Borchardt

Ru Zhou

Hui Li

Keith Brian Ryther

Thomas Jay Prins

Javier Gonzalez

Christopher S Crean

Wesley K Chong

Richard L Elliott

Tanya Michelle Jewell

Jerry Jialun Meng

Robert Fraser

Suzanne A Lebold

Kashinath Sadalapure

Tatyana V Khasanova

Charles S Agree

Carol McBride

Mikhail A Kondratenko

Jian-min Fu

Mikhail Chafev

Kashinath Sadalupure

Sun Shaoyi

Michael Winther

Heinz Gschwend

Combination compositions and kits comprising an analgesic and an antihistamine are provided as well as methods of use in treating sunburn.

Treatment of sunburn using analgesics and antihistamines

There are provided, inter alia, novel stabilized compositions for treating skin conditions wherein a therapeutically effective dosage of sulfur compound is applied which results in healing. The utilized dosage of sulfur compound results in a quicker breakdown of the virus capsid structure, resulting e.g., in faster healing. The dosing regimen to maintain the concentrations of the sulfur containing amino acid at the affected site also helps achieve quicker healing. The formulations and the methods are applicable to a variety of skin conditions including cold sores, herpes, genital herpes and shingles.

Healing topical composition

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): 

Pyridyl derivatives and their use as therapeutic agents

Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents

This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Yreceptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.

Non-nucleotide composition for inhibiting platelet aggregation

This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain. 

Combination therapy

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R, R, R, R, R, R, R, Ra, R, Ra, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Pyridazine derivatives and their use as therapeutic agents

The present invention is directed to a method of treating pain. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor antagonist. The methods of the present invention are useful in reducing pain, such as traumatic pain, neuropathic pain, organ pain and/or pain associated with diseases. The P2X receptor antagonists useful for this invention are non-nucleotide compounds of general Formula I. Compounds of Formula I can be used alone to treat pain. Compounds of Formula I can also be used in conjunction with other therapeutic agents or adjunctive therapies commonly used to treat pain, thus enhancing the therapeutic effect of pain reduction.

Non-nucleotide compositions and method for treating pain

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is &#x2014;O&#x2014;, &#x2014;N(R1)&#x2014;, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)&#x2014;, C(O)O&#x2014;, S(O)2&#x2014;, S(O)2N(R1)&#x2014; or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R9, R9, R10 and R10are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

This invention is directed to compounds of Formulae III and V, useful for treating diseases or conditions associated with platelet aggregation. 

Non-nucleotide composition and method for inhibiting platelet aggregation

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R, R, R, R, R, R, R, R, R, R, R, R, Rand Ra are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

Piperazine derivatives and their use as therapeutic agents

Growing community of inventors

Imperial Beach, CA, United States of America

Melwyn A Abreo