E.i. Dupont De Nemours and Company

The Dupont Merck Pharmaceutical Company

Melvyn J Myers

Victor J Nickolson

Richard A Earl

George A Boswell

Kyu T Lee

Victor J De Noble

Edward C Hermann

Kimi F De Noble

Cognitive defeciencies or neurological dysfunction in mammals are treated with .alpha.,.alpha.-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: ##STR1## or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;

.alpha.,.alpha.-disubstituted aromatics and heteroaromatics as cognition

.alpha., .alpha.-disubstituted aromatics and heteroaromatics as

This disclosure relates to a method of treating a neurological dysfunction in a mammal using a combination of at least one neurotransmitter enhancer and at least one serotonin receptor antagonist.

Method of treating neurological dysfunction using neutrotransmitter

N-oxide prodrug derivatives of 3-hydroxy morphinan and partial morphinan analgesics, agonist-antogonists, and narcotic antagonists are useful therapeutic entities which provide enhanced bioavailability of 3-hydroxy morphinans and partial morphinans from orally administered dosage forms.

N-oxide prodrug derivatives of 3-hydroxy morphinans and partial

Cognitive deficiencies and/or neurological function deficits and/or mood and/or mental disturbances are treated by the administration of 3,3-disubstituted indolines. The indolines have the formula: ##STR1## wherein: p is 0 or 1;

3,3-disubstituted indolines

N-oxide prodrug derivatives of 3-hydroxy morphinan and partial morphinan analgesics, agonist-antagonists, and narcotic antagonists are useful therapeutic entities which provide enhanced bioavailability of 3-hydroxy morphinans and partial morphinans from orally administered dosage forms.

This invention relates to a Tetrafluoroethyl Imidazole compound which shows potent antiinflammatory activity.

4,5-Bis-(4-fluorophenyl)-1-(4-nitrobenzyl

17-Substituted-6-desoxy-7,8-dihydro-6.alpha.-methylnoroxymorphone compounds corresponding to the formula ##STR1## The compounds exhibit narcotic antagonistic properties.

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Wilmington, DE, United States of America

Melvyn J Myers