Affymetrix, Inc.

Melvin Yamamoto

Chuan Gao

David Stern

Devin Nguyen

Glenn H McGall

Richard P Rava

Martin J Goldberg

Earl A Hubbell

MacDonald S Morris

Jennifer Dee Tan

Martin Diggelman

Nam Quoc Ngo

Ngo Quoc Nam

Dan Liu

John S Sze

Keith S Pearson

Philip C Trenholme

Chi Sou Yu

Clifford A Oostman, Jr

In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array. The method utilizes obtaining the best z position of the fiducials and using a surface fitting algorithm to produce a surface fit profile. One or more surface non-flatness parameters can be adjusted to improve the flatness image of the array surface to be imaged.

Methods and devices for reading microarrays

The present invention provides methods to process multiple sensors by providing a sensor plate and HT plates. In a preferred embodiment of the invention, methods for assembling microarray pegs and microarray plates are described for high throughput microarray processing.

Automated method of manufacturing polyer arrays

The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.

System for photolithographic synthesis of polymer arrays

Methods for photolithographic synthesis of polymer arrays utilizing anti-reflective coatings

Substrate preparation process

In one aspect of the invention, systems, methods, and devices are provided for creating microfluidic and nanofluidic structures. In some embodiments, such systems, methods, and devices are used to create features with high aspect ratios in lab cards.

System and method for making lab card by embossing

In one embodiment, fiber optic arrays or bundles are used as a light guide to transmit ultraviolet light to the substrate surface for photo-directed polymer synthesis. Digital Micromirror Array (DMA) is used as a switching device to reflect light onto the entry side of the fiber optic array.

Compositions and methods involving direct write optical lithography

Growing community of inventors

Fremont, CA, United States of America

Melvin Yamamoto