California Institute of Technology

University Technology Corporation

Aurora Biosciences Corporation

Melvin I Simon

David J Anderson

Xinzhong Dong

Mark Zylka

Sang-kyou Han

Stephen R Quake

Thomas J Meade

Charles S Zuker

Harry B Gray

Henry A Lester

Paul Negulescu

Toshihiko Takeuchi

Xiaoyan Bao

Johannes Schwarz

Stefan Offermanns

Jacqueline Agnan

Claude Selitrennikoff

Lisa A Alex

Ching-Kang Chen

Angelique Y Louie

The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

Pain signaling molecules

A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.

Method and device for regulating fluid flow in microfluidic devices

Assay employing G protein-coupled receptor expressed in dorsal root ganglia

The invention relates to an animal model for studying behavior related to RGS9 and RGS9 modulated dopamine D2-mediated behavior. The invention provides transgenic non-human animals in which RGS9 expression is disrupted, methods of using such animals, and methods of modulating dopamine D2-mediated behavior.

Transgenic mouse comprising a disruption in an RGS9 gene

The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.

Cobalt Schiff base compounds

Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.

Promiscuous G-protein compositions and their use

The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. albicans) and Neurospora (e.g., N. crassa). The present invention further provides compositions and methods for the development of antifungal compounds.

Osmosensing histidine kinases

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La Jolla, CA, United States of America

Melvin I Simon