Johnson Matthey Public Limited Company

Glaxosmithkline Australia Pty Limited

Alcaliber Investigacion Desarrollo E Innovacion Slu

Melville Mitchell

George Scott Wilson

Maureen Young

Neil John Goodwin

Craig Smith

Neil Kenneth Thomson

Stuart Purcell

Lucy Waddell

Nicholas Hayes

Jarrod Ritchie

Scott Brian Halliday

Maureen Joan Young

Santiago VÁZQUEZ Cruz

Oscar Lozano Ventura

Joan CASTAÑE Abrado

Andrés E Lukach Castore

A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CHor a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH)OH, C(CH)(C(CH))OH or COCH; Z is C-Calkyl or C-Carylalkyl; andis a single bond or a double bond, is disclosed. The process is a reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.

Preparation of opiate analgesics by reductive alkylation

A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CHor a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH)OH, (CH)(C(CH))OH or COCH; Z is C-Calkyl or C-Carylalkyl; andis a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.

This invention relates to intermediates useful in the preparation of opiate alkaloids, particularly morphinane compounds. The invention also relates to processes for preparing such intermediates and to processes which utilise such intermediates in the synthesis of morphinane compounds.

Process for the synthesis of morphinane compounds and intermediates thereof

Growing community of inventors

Edinburgh, United Kingdom

Melville Mitchell