Juno Therapeutics Gmbh

Memorial Sloan Kettering Cancer Center

Fred Hutchinson Cancer Center

Melissa Works

Eric L Smith

Yan Chen

Steven M Shamah

Csaba Pazmany

Semih Ullah Tareen

Jui Dutta-Simmons

Rupesh Amin

Collin Hauskins

Blythe D Sather

Aye Chen

Ruth Salmon

Kimberly Harrington

Rebecca Wu

Mariana Cota Stirner

Erik Hess

Cyr De Imus

Jon Jones

Audrey Olshefsky

Stefan Ponko

Stanley R Riddell

Yue Jiang

Damian J Green

Michael Ports

Timothy G Johnstone

Ronald James Hause, Jr

Stanley R Frankel

Heidi Jessup

Jim Shi Xiang Qin

Oleksandr Baturevych

David G Kugler

Catherine Sierra

Neha Soni

Jens Hasskarl

Michael Pourdehnad

Scott Hussell

Provided herein are chimeric receptors, including chimeric antigen receptors (CARs), comprising BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof, including heavy chain variable (V) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, including a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof including in adoptive cell therapy.

Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides

The present disclosure relates in some aspects to methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy, and an immunomodulatory compound, such as a structural or functional analog or derivative of thalidomide and/or an inhibitor of E3-ubiquitin ligase. The provided methods, compositions and uses include those for combination therapies involving the administration or use of one or more immunomodulatory compounds in conjunction with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR)-expressing T cells. Also provided are compositions, methods of administration to subjects, articles of manufacture and kits for use in the methods. In some aspects, features of the methods and cells provide for increased or improved activity, efficacy, persistence, expansion and/or proliferation of T cells for adoptive cell therapy or endogenous T cells recruited by immunotherapeutic agents.

Methods and combinations for treatment and T cell modulation

Provided herein are combination therapies involving administration of an immunotherapy involving a cell therapy, such as a T cell therapy, and an inhibitor of gamma secretase. Also provided are methods for engineering, preparing, and producing the cells, compositions containing the cells and/or gamma secretase inhibitor, and kits and devices containing and for using, producing and administering the cells and/or gamma secretase inhibitor, such as in accord with the provided combination therapy methods.

Combination of a cell therapy and a gamma secretase inhibitor

Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (V) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

Growing community of inventors

Seattle, WA, United States of America

Melissa Works