Medimmune Limited

Melissa Hamilton

Christine Tkaczyk

Lei Hua

Brett R Sellman

Bret Sellman

The present invention provides for methods of preventing and/or treating-associated bacteremia and sepsis, and methods for preventing and/or treating-associated pneumonia in immunocompromised patients using anti-alpha-toxin (anti-AT) antibodies. Also provided are methods of reducingbacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducingbacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity ofassociated pneumonia in an immunocompromised mammalian subject.

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Gaithersburg, MD, United States of America

Melissa Hamilton