Sp Industries, Inc.

Praxair Technology, Inc.

Melinda Lee Verdone

Theodore Hall Gasteyer

Robert Rex Sever

Balazs Hunek

Nigel Grinter

Theodore Hall Iii Gasteyer

System and method for lyophilization or freeze-drying is provided. During the freezing step, the material or solution to be frozen is initially brought to a temperature near or below its freezing temperature after which the pressure in the freeze-dryer chamber is reduced to induce nucleation of the material.

Lyophilization system and method

Methods of inducing nucleation of a material is provided. The disclosed methods comprise the steps of bringing the material to a temperature near or below a phase transition temperature and altering the pressure to induce nucleation of the material. The disclosed methods are useful in freeze-drying processes, particularly pharmaceutical freeze-drying processes.

Method of inducing nucleation of a material

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Hoffman Estates, IL, United States of America

Melinda Lee Verdone