King Fahd University of Petroleum and Minerals

Melendran Pillay

Katharigatta N Venugopala

Mohamed A Morsy

Pran Kishore Deb

Sandeep Chandrashekharappa

Bandar Aldhubiab

Rashmi Venugopala

Osama I Alwassil

Nagaraja Sreeharsha

Mahesh Attimarad

Anroop B Nair

Vijaykumar Uppar

Basavaraj Padmashali

Shashiprabha S

Nefisath P

Jagadeesh Prasad Dasappa

Christophe Tratrat

Sheena Shashikanth

Amit Kumar

Mahmoud Kandeel

Vinuta Kamat

Keshab M Bairagi

Susanta K Nayak

Sandeep Chandrashekarappa

Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide as anti-tubercular agents

Novel arylhydrazones derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The arylhydrazones derivative compounds are useful as anti-tubercular agents.

(E)-2-(3-Cyano-4-isobutoxyphenyl)-N'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

(E)-2-(3-cyano-4-isobutoxyphenyl)-n'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are substituted 1,3,4-oxadiazole derivatives and their use as anti-tubercular agents are provided.

Substituted 1,3,4-oxadiazole derivatives as anti-tubercular agents

Novel oxoimidazolidine derivative compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The oxoimidazolidine derivative compounds are useful as anti-tubercular agents.

Oxoimidazolidine derivatives as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 5-(1H-indol-3-yl)-1,3-substituted-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives and their use as anti-tubercular agents. Each compound may have the formula I:

Substituted 7,8-dihydropyrimido[4,5-d]pyrimidines as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are substituted 7-amino-3-(substituted benzoyl)indolizine-1-carboxylates and their use as anti-tubercular agents.

Substituted 7-amino-3-(substituted benzoyl)indolizine-1-carboxylates as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 1-(2-(substitutedphenyl)-2-oxoethyl)-3,5-dimethylpyridin-1-ium bromides and their use as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-3,5-dimethylpyridin-1-ium bromides as antitubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are ethyl 2-substitued-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives and their use as anti-tubercular agents are provided.

Ethyl 2-substituted-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, antitubercular compounds that are substituted 7-methyl quinoline derivatives and their use as antitubercular agents are provided.

Substituted 7-methyl quinoline derivatives as antitubercular agents

Novel-(-(substituted phenyl)--oxoethyl)--(isopropoxycarbonyl)pyridin--ium bromide derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The-(-(substituted phenyl)--oxoethyl)--(isopropoxycarbonyl)pyridin--ium bromide derivative compounds are useful as anti-tubercular agents.

1-2(-(substituted phenyl)-2-oxoethyl)-4-(isopropoxycarbonyl)pyridin-1-ium bromides as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are (6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones and their use as anti-tubercular agents are provided.

(6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones as antitubercular agents

The substituted indolizine dicarboxylates are antibacterial agents. The emergence of drug-resistant bacteria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug sensitive and resistant bacteria and are well tolerated. The present compounds are not only new, but have very valuable antimicrobial properties. These compounds showed a broad spectrum of activity against tuberculosis mycobacteria. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.

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Durban, South Africa

Melendran Pillay