Basf Se Corporation

Ruprecht-karls-universitat Heidelberg

Melanie Weingarten

Wolfgang Siegel

Michael Puhl

Ralf Pelzer

Michael Breuer

Florian Garlichs

Hansgeorg Ernst

Miriam Bru Roig

Manuel Danz

Volker Hickmann

Ekkehard Winterfeldt

Silke Weyland

Reinhard W Hoffmann

Rocco Paciello

Klaus Ditrich

Stefan Rüdenauer

Andreas Keller

Kai-Uwe Baldenius

Mathias Schelwies

Peter Hofmann

Julia Strautmann

Vaidotas Navickas

Stefan Ruedenauer

Helmut Kronemayer

Pepa Dimitrova

Christian Rein

Sebastian Schmidt

The present invention relates to substituted 4-methylene-tetrahydropyrans, 4-methyl-dihydropyrans and 4-methyl-tetrahydropyrans of formula (I), where the variables are as defined in the claims and description, to a stereoisomer thereof, to a mixture of stereoisomers thereof, to a mixture of different di- and tetrahydropyrans (I) and to a mixture containing at least one di- or tetrahydropyran (I) and at least one cyclic acetal which is a 1,3-dioxan carrying in 2-position an isobutanol-2-yl-(derived) substituent and in 4,4- or 5,5-position two methyl substituents. The invention also relates to the use of such compounds as an aroma chemical and/or for modifying and/or enhancing the aroma of a composition, to compositions comprising such compounds, to methods for preparing such compounds and to a product obtainable by these methods.

Substituted 4-methylene-tetrahydropyrans, 4-methyl-dihydropyrans and 4-methyl-tetrahydropyrans and use thereof as aroma chemicals

The present invention relates to 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde and derivatives thereof, to a process for preparing said compounds, to the use of 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or of mixtures of said compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use of 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof for modifying the scent character of a fragranced composition; to compositions containing 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition, comprising incorporating 2-(2,4,5-trimethylcyclohex-2-en-1-yl)-acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof into said composition.

2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde and derivatives and their use as aroma chemicals

The presently claimed invention is directed to the use of 1-alkoxyethyl-4-isobutyl-benzene of formula (I) to impart an aroma impression to a composition. The presently claimed invention also relates to a method of imparting such aroma impression. The present invention is further directed to compositions comprising the compound of formula (I) and at least one aroma chemical as well as to compositions comprising the compound of formula (I) and at least one further component selected from the group consisting of aroma chemicals, surfactants, oil components, anti-oxidants, deodorant-active agents and solvents. The present invention also relates to a compound of formula (I').

1-alkoxyethyl-4-isobutyl-benzene as aroma ingredients

The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives

The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R, Rand Rindependently of each other are selected from hydrogen and methyl, Ris selected from hydrogen and C-C-alkanoyl, and X is selected from C-C-alkyl and C-C-alkenyl.

Synthesis of chromanol derivatives

The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R, Rand Rindependently of each other are selected from hydrogen and methyl, Ris selected from C--C-alkyl, and X is selected from C-C-alkyl and C-C-alkenyl. 

The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(&#x2212;)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

Method for the preparation of (3E,7E)-homofarnesic acid or (3E,7E)-homofarnesic acid ester

The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2&#x2032;-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C-C-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base.  In the formulae (I) and (II), the variables are each defined as follows:

Method for preparing 2'-O-fucosyllactose

The present invention relates to a method for preparing a dialkyi or dialkenyl ether of a cycloaliphatic or araliphatic diol, which comprises (i) reacting the cycloaliphatic or araliphatic diol with metallic sodium in an aprotic organic solvent in the presence of a catalytic amount of at least one monoether-monoalcohol of formula (I) wherein Y is identical or different and selected from C-C-alkylene, n is an integer in the range from 1 to 10, and Ris C-C-Alkyl, whereby the corresponding disodium dialcoholate is obtained, reacting the disodium dialcoholate obtained in step (i) with an alkylation alkenylation reagent. 

Method for preparing ethers of cycloaliphatic or araliphatic diols

The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.

Biocatalytic production of l-fucose

The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

Method for the hydroformylation of 2-substituted butadienes and the production of secondary products thereof, especially ambrox

The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations with an increased content of (3E,7E)-homofarnesol (also referred to as all E-homofarnesol).

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Ratzeburg, Germany

Melanie Weingarten