University of Michigan

Dow Global Technolgoies LLC

Dow Agrosciences LLC

Other

University of Illinois

Melanie S Sanford

Douglas Bland

Patrick S Hanley

Megan A Cismesia

Sydonie D Schimler

Laura Allen

Robert H Grubbs

Yang Cheng

Jason Lee Moore

Tina M Trnka

Jennifer A Love

Shin Hee Lee

Gary A Roth

Joseck M Muhuhi

Peter J H Scott

Sarah Ryan

Etienne Chénard

Rachel Brooner

Christo Slavov Sevov

Joseph J Topczewski

Melissa Rodnick

Allen F Brooks

Naoko Ichiishi

Patrick S Hanly

Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SOFto a reaction mixture; reacting the SOFand the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar&#x2014;OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SOFto the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SOF, the fluorinating reagent and the compound having the structure Ar&#x2014;OH to provide a fluorinated aryl species having the structure Ar&#x2014;F.

Method for aromatic fluorination

Disclosed is a fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar&#x2014;X to the reaction mixture; wherein Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is Cl, Br, I or NO, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar&#x2014;F.

Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.

Organic anolyte materials for flow batteries

Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SOFto a reaction mixture; reacting the SOFand the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar&#x2014;OH to a reaction mixture; where A is an aryl or heteroaryl; providing SOFto the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SOF, the fluorinating reagent and the compound having the structure Ar&#x2014;OH to provide a fluorinated aryl species having the structure Ar&#x2014;F.

Copper-catalyzed radiofluorination of iodonium salts, iodonium salts, and compounds obtained by copper-catalyzed radiofluorination of iodonium salts are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.

Copper catalyzed [18F]fluorination of iodonium salts

Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate.

Process for fluorinating compounds

Disclosed are mild temperature (e.g., from 0 to 80&#xb0; C.) SAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMeF.

Methods of preparing a fluorinated substrate by combining potassium fluoride, a quaternary ammonium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed.

Methods of preparing a fluorinated substrate by combining potassium fluoride, imidazolium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed.

Growing community of inventors

Ann Arbor, MI, United States of America

Melanie S Sanford