Genentech, Inc.

Genetech, Inc.

Other

New England Deaconess Hosp.

New England Deaconess (ned) Hospital

Melanie Rose Mark

Paul J Godowski

Michael D Sadick

Natalie A Lokker

R Glenn Hammonds, Jr

Wai Lee Wong

David T Scadden

Dong Xiao Zhang

Austin L Gurney

Audrey Goddard

Jennie Powell Mather

Jian Chen

David L Shelton

Ronghao Li

Dong-Xiao Zhang

Ruey-Bing Yang

Wai Lee Tan Wong

The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285, PRO286, and PRO358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285, or PRO286, or PRO358 Toll protein.

Antibodies that bind to PRO286

The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

Methods of stimulating ErbB4 receptor phosphorylation

The invention relates to the identification and isolation of DNAs encoding the human Toll proteins PR0285, PR0286, and PR0358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PR0285, or PR0286, or PR0358 Toll protein.

Antibodies to human Toll homologues

ErbB4 receptor-specific neuregulin related ligands and uses therefor

Kinase receptor activation assay

An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides variant gas6 polypeptides, compositions comprising variant gas6 polypeptides, nucleic acids encoding variant gas6 polypeptides, vectors comprising those nucleic acids and host cells comprising those vectors. The present invention is further directed to methods for making variant gas6 polypeptides.

Variant gas6 polypeptides

ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor

An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides compositions comprising gas6 polypeptides wherein the gas6 polypeptides are present in an amount effective for activating the Rse receptor. The present invention is further directed to articles of manufacture comprising gas6 polypeptides such as kits and containers containing gas6 polypeptide compositions and gas6 polypeptide In a liposome or adsorbed to a membrane.

Compositions comprising gas6 polypeptides and articles of manufacture comprising the same

The translation product of the growth arrest-specific gene 6 (gas6) has been identified as an activator of the Mer receptor protein tyrosine kinase. The invention accordingly provides methods of activating Mer receptor in cells expressing it by exposing them to exogenous gas6 polypeptides. Also provided are methods of enhancing the growth, differentiation, or survival of such cells using gas6 polypeptides.

Mer receptor activation by gas6

ErbB4 receptor-specific neuregolin related ligands and uses therefor

The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.

Nucleic acids encoding protein tryosine kinases

Protein tyrosine kinases

An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides a method of activating the Rse receptor by exposing a cell comprising the Rse receptor to exogenous gas6 polypeptide. Moreover, the present invention is directed to a method for enhancing the survival, proliferation or differentiation of a cell comprising a Rse receptor by exposing the cell to exogenous gas6 polypeptide. The types of cells which can be treated according to the method include glial cells such as Schwann cells.

Rse receptor activation

Growing community of inventors

Burlingame, CA, United States of America

Melanie Rose Mark