Apotex Inc.

Melanie R A Green

Prabhudas Bodhuri

Gamini Weeratunga

Boris Gorin

Avedis Karadeolian

Stuart P Green

Alfredo Paul Ceccarelli

Eduardo Gustavo Cammisa

Kaarina K Milnes

The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1). 

Process for the preparation of acalabrutinib

The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1). 

Processes for the preparation of Veliparib and intermediates thereof

The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1). 

Processes for the preparation of lesinurad and intermediates thereof

The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.

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Milton, Canada

Melanie R A Green