Immunex Corporation

Other

Melanie K Spriggs

William Christian Fanslow, Iii

Richard Jeffrey Armitage

Zhengbin Yao

Subhashini Srinivasan

Michael R Comeau

Marylou G Gibson

Robert F DuBose

Richard S Johnson

Mark R Alderson

Arvia Eleanor Morris

Jeffrey T McGrew

William C Fanslow, Iii

Jeffrey I Cohen

Theresa M Farrah

Michael B Widmer

Lindsey M Hutt-Fletcher

Blair R Renshaw

Barry L Davison

Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.

Methods of treating asthma by administering interleukin-17 receptor

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor and lack native-pattern glycosylation.

CD40-Ligand lacking native-pattern glycosylation

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.

Mouse CD40 ligand-specific antibodies and hybridomas

Methods of treating allergy by administering interleukin-17 receptor

The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.

Viral encoded semaphorin protein receptor DNA and polypeptides

Methods of treating autoimmune disease by administering interleukin-17 receptor

This invention provides a method comprising assaying the binding of a DCSema polypeptide to a VESPR protein.

Semaphorin polypeptides

CD4 cells obtained from individuals with defective CD40L gene and transfected with a vector containing CD40-L are described.

Defective CD4&plus;T-cells that express active CD40-L

Antibodies to viral encoded semaphorin protein receptor polypeptides

DNA encoding CD40 ligand, a cytokine that binds CD40

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ligand polypeptide that stimulates B cell proliferation.

Use of CD40 ligand, a cytokine that binds CD40, to stimulate hybridoma cells

Method of augmenting a vaccine response by administering CD40 ligand

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of inhibiting undesirable immune responses, preventing T cell interaction with B cells by blocking CD40L binding to CD40 sites on B cells and other target cells.

Methods of inhibiting CD40L binding to CD40 with soluble monomeric CD40L

Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, detection assays and methods of inhibiting binding of the receports are disclosed. The isolated receptors can be used to regulate an immune response.

Assay kits for detection and methods of inhibiting IL-17 binding

Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can be used to regulate an immune response.

Growing community of inventors

Seattle, WA, United States of America

Melanie K Spriggs