Basf Se Corporation

Melanie Bonnekessel

Christopher Koradin

Manfred Ehresmann

Andreas Pletsch

Thomas Kaeding

Wolfgang Siegel

Bernhard Hauer

Hartwig Schröder

Hartwig Schroeder

Klaus Ditrich

Stephan Maurer

Wolfgang Ladner

Stephan Freyer

Kurt Faber

Rene Backes

Bryan Cooper

Franz Weber

Wolfgang Reichert

Ekkehard Winterfeldt

Peter Oedman

Burkhard Ernst

Steffen Maurer

Stefanie Demming

Reinhard W Hoffmann

Jürgen Däuwel

Clemens Stückler

Ralf Hoock

Achim Sorg

Karin Schein-Albrecht

Hartwig SCHRÖDER

Hansgeorg Ernst

Peter ÖDman

The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.

Production of pyripyropenes from dry biomass

The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i). 

Method for preparing a pyripyropene compound

The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.

Preparation of isomerically pure substituted cyclohexanols

A process for the enzymatic reduction of an enoate (1) wherein the C&#x2550;C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (&#x2014;CRO), an aldehyde radical (&#x2014;CHO), a carboxyl radical (&#x2014;COOR), with R&#x2550;H or optionally substituted C-C-alkyl radical, R, Rand Rare independently of one another H, &#x2014;O&#x2014;C-C-alkyl, &#x2014;O&#x2014;W with W=a hydroxyl protecting group, C-C-alkyl, which can be substituted, C-C-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R, Rand Ris a &#x2014;OH radical, or Ris linked to Rso as to become part of a 4-8-membered cycle, or Ris linked to R so as to become part of a 4-8-membered cycle, with the proviso that R, Rand Rmay not be identical.

Process for the enzymatic reduction of enoates

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Ludwigshafen, Germany

Melanie Bonnekessel