Juno Therapeutics Gmbh

Mel Davis-pickett

Jeff D Smith

Mark J Gilbert

He Li

Christopher Glen Ramsborg

Pascal Beauchesne

Ryan P Larson

Claire L Sutherland

Clinton Weber

Valerie Odegard

Kathryn Lindsay Pollock

Tom Kowski

Brian Christin

Nathan K Yee

Andrew W Walker

Mary Mallaney

Kedar Himanshu Dave

Michael Gerard Covington

Richard James Getto, Jr

James Boyd Whitmore

Travis Beckett

Samuel Charles Blackman

Nathaniel Chartrand

Nathaniel Lambert

Nikolaus Sebastian Trede

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Determining toxicity risk in CAR T-cell therapy

Growing community of inventors

Seattle, WA, United States of America

Mel Davis-pickett