Quantum-Si Incorporated

Mel Davey

Jonathan Marc Rothberg

Brett J Gyarfas

Keith Glen Fife

Todd Rearick

Jeremy Christopher Jordan

Benjamin Cipriany

Brian Reed

Faisal R Ahmad

Jimmy Jia

Michael Ferrigno

Jonathan M Rothberg

Joseph D Clark

Tom Thurston

Craig Wenger

Daniel B Frier

Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.

Data acquisition control for advanced analytic instruments having pulsed optical sources

System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.

Pulse caller and base caller

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Westbrook, CT, United States of America

Mel Davey