Yeda Research and Develpment & Co. Ltd

Research Foundation for Mental Hygiene, Inc.

Biosepra Inc.

Ciphergen Biosystems, Inc.

Meir Wilchek

Edward A Bayer

Alexander Schwarz

David Mirelman

Aharon Rabinkov

Talia Miron

Heike Hofstetter

Margherita Morpurgo

Stephen E Karpiak

Hadassah Tamir

Ruth Arnon

Alexander Rich

Marian Gorecki

Abraham Warshawsky

Bilha Schechter

Janina Altman

Hephzibah Sivaraman

Karin Cabrera

Ely Morag

Clemenceau T Acquaye

Varda Gilad

Gad Gilad

Nurit Shoef

Conjugates of the enzyme alliinase with a protein carrier that targets the alliinase to specific cells are used in combination with alliin to produce allicin at a desired target site. The enzyme converts alliin to allicin at the target site to kill cancer cells or pathogens.

Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases

Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin.

Allylmercaptocaptopril compounds and uses thereof

A covalent conjugate of a 4'-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH)or &#x2014;CH&#x2550;CH&#x2014;, wherein n is an integer from 0&#x2013;10; B is (CH)wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.

Avidin derivatives and uses thereof

Immobilized garlic alliinase wherein the alliinase is chemically, physically or biologically immobilized, is useful in a method for continuous production of allicin. The method comprises adding a solution of alliin as substrate to a column containing the immobilized garlic alliinase and collecting pure allicin in the effluent. The pure allicin is intended for use as food additive or for the preparation of pharmaceutical compositions for the treatment of viral, bacterial, fungal and parasitic infections, high levels of cholesterol and blood lipids, high blood pressure and thrombosis.

Garlic alliinase covalently bound to carrier for continuous production of allician

The present invention relates to avidin-type molecules having 2,4,6-trinitrophenyl or lactosyl groups or being complexed with an antibody specific to the avidin-type molecule, which shifts the biodistribution pattern in tissues and organs to the liver, where these molecules accumulate at high levels over several days. These modified avidin-type molecules provide a means for delivery of diagnostic and therapeutic agents, including radionuclides to the liver and cells of the reticuloendothelial system (RES) for diagnosing and treating hepatic disorders and disorders of the RES.

Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system

Chromatography adsorbents utilizing mercapto heterocyclic ligands

Azobenzene derivatives as labeling agents and intermediates thereof

Modified avidin and streptavidin molecules and use thereof

A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent includes: (a) a solid support material; and (b) a ligand immobilized on the surface of the solid support material, said ligand being a compound of the formula ##STR1## wherein Y.sub.1 is selected from the group of S, SCH.sub.3.sup.+, O, NH, NCH.sub.3, CH.sub.2 and CR.sub.1 R.sub.2 wherein at least one of R.sub.1 and R.sub.2 is not hydrogen; wherein each of Y.sub.2, Y.sub.3 and Y.sub.4 is selected from the group of N, NCH.sub.3.sup.+, CH, and CR wherein R is not hydrogen; and wherein at least two of Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are neither CH.sub.2, CH, CR nor CR.sub.1 R.sub.2.

A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent comprises: (a) a solid support material; and (b) a ligand immobilized on the surface of the solid support material, said ligand being a compound of the formula ##STR1## wherein Y.sub.1 is selected from the group consisting of S, SCH.sub.3.sup.+, O, NH, NCH.sub.3, CH.sub.2 and CR.sub.1 R.sub.2 wherein at least one of R.sub.1 and R.sub.2 is not hydrogen; wherein each of Y.sub.2, Y.sub.3 and Y.sub.4 is selected from the group consisting of N, NCH.sub.3.sup.+, CH, and CR wherein R is not hydrogen; and wherein at least two of Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are neither CH.sub.2, CH, CR nor CR.sub.1 R.sub.2.

The invention relates to modified silica, substituted with a variety of substituents. There is provided a product termed primary hydroxyl silica where there are attached to the silica substituents bearing a single hydroxyl group. Furthermore there are provided a wide variety of derivatives of such hydroxy-silica, which are of value in affinity chromatography and for various other uses. The products combine the thermal and mechanical stability of the silica used as carrier with the useful properties of the substituents.

Substituted silica

Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C.sub.2 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.16 alkenyl, C.sub.2 -C.sub.16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;

N-acylated 5-hydroxytryptophan amide derivatives

There are provided bifunctional chelating agents, which are analogues of EDTA, conjugates of same with a variety of haptens and conjugates of such conjugates with haptens with certain metals, forming metal complexes. The metal complexes have a variety of uses, among these various assays for the determination of haptens and macromolecules. There is also provided a process for the production of the above. There are provided radioimmunoassays based on the above conjugates with metal cations.

Growing community of inventors

Rehovot, Israel

Meir Wilchek