Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Bio-technology General Corporation

American National Red Cross

Choay, S.a.

Biophram (uk) Limited

Meir Rigbi

Craig M Jackson

Avigdor Levanon

Pierre Lefrancier

Moshe M Werber

Elisha P Zeelon

Rachel Guy

Meir Fischer

Amos Panet

Roy T Sawyer

Edgar Sache

Amiram Eldor

Miriam Orevi

Haim Levy

Arie Goldlust

Fuad Iraqi

Yakir Klausner

The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr.sup.26 -gly.sup.110 where tyr.sup.26 -gly.sup.110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn.sup.72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.

Production of recombinant factor Xa inhibitor of leech Hirudo

A novel anticoagulant/modulator factor isolated from the saliva of the meinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.

Factor Xa inhibitor and pharmaceutical compositions containing same

A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of the Hirudinidae family. The composition contains various components, all having molecular weights lower than 2,000 daltons. The composition has an inhibitory activity against platelet aggregation induced by various aggregating agents, including Platelet Activating Factor-acether (PAF-acether), arachidonic acid, thrombin, ADP and epinephrine.

Platelet-aggregating inhibitory agents from leech saliva and

A novel anticoagulant/modulator factor isolated from the saliva of the medicinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.

Factor Xa inibitor from leech and pharmaceutical compositions containing

Collagen-specific enzyme with platelet aggregation inhibition properties

The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine. The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.

Derivatives of para-guanidino-L-phenylalanine and methods of preparing

Growing community of inventors

Jerusalem, Israel

Meir Rigbi