Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Other

Teva Pharmaceutical Industries Limited

Yissum Research and Development

Meir Bialer

Boris Yagen

Mitchell Shirvan

Michael M Friedman

Jeff Sterling

Nina Isoherranen

Ofer Spigelstein

Dan Kaufmann

David Lerner

Yaacov Herzig

Arie Dagan

Abdullah Ibrahim Haj-Yehia

Michael Roeder

Jacob Herzig

Marshall Devor

Hussein Ziad

Salim Hadad

Upd Dufrovsky

Avraham Rubinstein

Sussan Sherbel

Ofer Spiegelstein

Volker Schurig

Jakob Avi Shimshoni

Eyal Sobol

Neta Pessah

Yagen Boris

Novel acyl-urea containing compounds, processes of preparing same, compositions containing same and uses thereof in the treatment of neurological diseases and disorders such as epilepsy, neuropathic pain, bipolar disorder, status epilepticus, chemically-induced convulsions and/or seizure disorders, febrile convulsions conditions, metabolic disturbances and a sustenance withdrawal conditions, are provided. Also provided are uses of these and other acyl-urea containing compounds in the treatment of neurological diseases and disorders.

Acyl-urea derivatives and uses thereof

Amide derivatives of valproic acid are provided along their use in the treatment of epilepsy.

Amide derivatives of valproic acid and uses thereof

Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided.

Alpha-halo- and alpha-alkyl-cyclopropylcarboxy compounds and uses thereof

The invention relates to the use of valnoctamide (VCD) for the treatment of bipolar disorder and in particular for the treatment of the manic phase of the bipolar disorder.

Compounds useful for treating bipolar disorders

A method for the treatment or prevention of pain and/or a headache disorder using a derivative of a valproic acid amide or a 2-valproenic acid amide, as well as pharmaceutical compositions comprising these derivatives or compounds.

Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders

The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.

Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid

The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl acetamide and their isomers in their racemic and stereospecific forms, for use in treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines. The isomers are of the compound formula I The present invention further relates to a method for the stereoselective synthesis of the 2R stereoisomer of PID and PIA. The present invention also relates to pharmaceutical compositions containing as an active ingredient a racemic mixture or stereoisomers of the compounds of the general formula (I), which are useful for the treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines.

Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them

New derivatives of N-Hydroxyalkyl-tetramethylcyclopropane carboxamide, pharmaceutical compositions thereof, methods for their preparation, and use thereof for the treatment of epilepsy, neurological, affective and psychotic disorders and for the treatment of pain and migraine.

Derivatives and pharmaceutical compositions of n-hydroxyalkyl tetramethylcyclopropane-carboxamide, having anti-epiletic, neurological, and CNS activity, and method for their preparation

The invention relates to derivatives of valproyltaurinamide of formula (I) in which Rand Rare independently hydrogen, a C-C-alkyl group, an arylalkyl group or an aryl group. The derivatives are especially useful for the treatment of epilepsy, affective illness, cognitive disorders, neurodegenerative disease, neuropathic pain syndrome, migraine, stroke, brain ischemia, or head trauma injury.

Valproyltaurinamide derivatives as anticonvulsant amd CNS active agents

Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder

The present invention generally relates to the individual stereoisomers of the drug valnoctamide (a mixture of four stereoisomer kinds, VCD-valmethamide or 2-ethyl-3-methyl pentanamide) useful in treatment of neurological and psychotic disorders such as different kinds of epilepsy and affective disorders, and useful as tranquilizers and to treat pain, and to pharmaceutical compositions containing, as an active ingredient, these stereoisomers. The present invention further relates to a method for stereoselective separation and quantification of the four stereoisomers from a racemic mixture of VCD or plasma of patients treated with the racemic drug. The present invention further relates to a unique method for the synthesis of the individual stereoisomers.

Amelioration of neurological disorders by the administration of (2R),(3S), and/or (2S),3(S) stereoisomers of valnoctamide

According to the present invention, anticonvulsant compounds N-acetyl,N'-benzylglycinamide and N-benzyloxycarbonylglycinamide-Z-glycinamide are disclosed. The present invention also discloses an anticonvulsant pharmaceutical composition comprising an effective amount of at least one active ingredient selected from N-acetyl,N'-benzylglycinamide and N-benzyloxycarbonylglycinamide-Z-glycinamide and a pharmaceutically acceptable carrier or diluent. The present invention provides a method of controlling convulsions in a mammal by administering to the mammal an effective amount of antiepileptic compounds N-acetyl,N'-benzylglycinamide or N-benzyloxycarbonylglycinamide-Z-glycinamide. Combinations of the anticonvulsion compounds can also be administered. The convulsions may be due to epilepsy, febrile convulsions or convulsions precipitated by irritative lesions in the brain. Further the composition may be used to prevent migraine and to treat chronic pain and bipolar disorder.

Anticonvulsant drugs and pharmaceutical compositions thereof

Derivatives of tetramethylcyclopropane

A compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently the same or different and are hydrogen, a C.sub.1 -C.sub.6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3. Also provided are a compound containing a 2-valproenoic moiety, pharmaceutical compositions comprising these compounds, and methods of using them for the effective treatment of epilepsy and other neurological disorders.

Growing community of inventors

Jerusalem, Israel

Meir Bialer