American Home Products Corporation

Other

Meier E Freed

John R Potoski

Magid A Abou-Gharbia

James L Diebold

Thomas J Colatsky

This invention concerns tetrahydropyridoindoles of the formula: ##STR1## wherein Q represents ##STR2## in which R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or --COO(C.sub.1-2) alkyl, and n is an integer from 1 to 7; R.sub.1 is hydrogen, halogen, hydroxy, or C.sub.1-3 alkyl; and R.sub.2 is hydrogen, C.sub.1-4 alkyl or --(CH.sub.2).sub.m --A where A is --N(CH.sub.3).sub.2,--N(C.sub.2 H.sub.5).sub.2, ##STR3## in which Ar is 2-pyrimidinyl, 2-pyrazinyl, phenyl, or phenyl substituted by a methyl, ethyl, methoxy, ethoxy, or trifluoromethyl group; and m is an integer from 1-4, or physiologically acceptable salts thereof, providing however that when n is 1, Q may not be quinolinyl. These compounds exhibit antihypertensive properties. Four of the disclosed compounds also exhibit antipsychotic properties. Also disclosed are compounds of Formula XX in which Q of Formula I is replaced by Q.sub.1, wherein Q.sub.1 is 2- or 3-pyridinyl, and R.sub.2 of Formula I is restricted to hydrogen. The compounds of Formula XX exhibit antipsychotic properties.

2,3,4,9-tetrahydro-2-heteroarylalkyl-1H-pyrido(3,4-B)indoles having

This invention provides a group of antiarrythmic agents of the formula: ##STR1## in which R.sub.1 is --CO.sub.2 H, --CO.sub.2 (CH.sub.2).sub.n --NR.sub.4 R.sub.5, --CONR.sub.6 R.sub.7, --NHCO.sub.2 R.sub.8 or --NHCO.sub.2 (CH.sub.2).sub.o --NR.sub.9 R.sub.10 where R.sub.4 and R.sub.5 are H or alkyl of 1 to 6 carbon atoms and n is 1 to 6; R.sub.6 and R.sub.7 are H or alkyl of 1 to 6 carbon atoms; R.sub.8 is alkyl of 1 to 6 carbon atoms; and R.sub.9 and R.sub.10 are alkyl of 2 to 6 carbon atoms and o is 1 to 6;

Antiarrhythmic agents

There are disclosed compounds having the formula ##STR1## wherein X is a group selected from ##STR2## Y represents a single or double bond; R.sup.1 is hydrogen or lower alkyl;

Substituted bi-alicyclic imides

This invention provides a group of antiarrhythmic agents of the formula: ##STR1## in which R.sub.1 is --CO.sub.2 H, --CO.sub.2 (CH.sub.2).sub.n --NR.sub.4 R.sub.5, --CONR.sub.6 R.sub.7, --NHCO.sub.2 R.sub.8 or --NHCO.sub.2 (CH.sub.2).sub.o --NR.sub.9 R.sub.10 where R.sub.4 and R.sub.5 are H or alkyl of 1 to 6 carbon atoms and n is 1 to 6; R.sub.6 and R.sub.7 are H or alkyl of 1 to 6 carbon atoms; R.sub.8 is alkyl of 1 to 6 carbon atoms; and R.sub.9 and R.sub.10 are alkyl of 2 to 6 carbon atoms and o is 1 to 6;

Antiarrhythmic cyclooct[b]indoles

Benzocycloalkane amine derivatives and their non-toxic acid addition salts as novel analgesic agents.

Benzocycloalkane amines

Compounds of the formula: ##STR1## in which R is alkyl or aralkyl,

Hypotensive agents

Tetra- and hexa-hydropyrrolo[1,2-a]quinoxaline and azaquinoxaline derivatives of the formula: ##STR1## in which X is O or H.sub.2 ;

Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline

The compounds ##STR1## where R is hydrogen, alkyl, phenyl or substituted phenyl and R.sup.1 is 2-furanyl, 2-benzofuranyl, 2-thienyl or 2-pyridyl or pharmaceutically acceptable salts thereof are antihypertensive, antisecretory agents.

4-Substituted-piperidino carboxamides

The compounds ##STR1## where R is hydrogen, alkyl, phenylalkyl or dialkylamino alkyl;

2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids

There are disclosed 2,6-bis-(pyrrolopyrazinyl)pyrazines which exhibit antihypertensive activity.

2,6-Bis-(pyrrolopyrazinyl)pyrazines

Aryl-1-mercaptoalkanoylproline and homoproline derivatives and their cyclized thiazadione heterocyclic analogues reduce blood pressure in animals by ACE inhibition.

Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones

Aryl-1-mercaptoalkanoylproline and homoproline derivatives

The thiazepino-[4,3-b]-isoquinoline-1,5-diones of the formula: ##STR1## where R.sup.1 is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms or halo;

Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors

Compounds of the formula ##STR1## wherein: R is hydrogen, chlorine, or fluorine; and

Tetrahydro(1H)pyrazino(1,2-A)azaquinoxalin-5(6H)-ones and derivatives

Disclosed herein are compounds of the formula: ##STR1## wherein n is an integer from 1 to 8;

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Paoli, PA, United States of America

Meier E Freed