National Institutes for Quantum and Radiological Science and Technology

Public University Corporation Yokohama City University

Meiei Cho

Tetsuya Suhara

Makoto Higuchi

Masahiro Maruyama

Hitoshi Shimada

Tomoyuki Miyazaki

Takuya Takahashi

The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof:

Compounds for imaging tau proteins that accumulate in the brain

The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein:  represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.

Compounds for imaging tau proteins that accumulate in brain

The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: 

The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. (In the formula, each of A and Z independently represents CO, SO or SO; each of X and Y independently represents S or O; each of R-Rindependently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each Rindependently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.

Growing community of inventors

Chiba, Japan

Meiei Cho