Industrial Technology Research Institute

Mei-Wei Lin

Min-Yuan Chou

I-Horng Pan

Yi-Cheng Cheng

Zong-Keng Kuo

Tien-Soung Tong

Hsin-Chieh Wu

Li-Tsen Lin

Hsin-Jan Yao

I-Huang Lu

Hsiang-Wen Tseng

Ya-Ping Lai

Yen-Ju Lin

Ching-Huai Ko

Shyh-Horng Lin

Chung-Yuan Sun

Ssu-Yuan Wu

Chin-Pen Lai

Chun-Chung Wang

A method for screening host cells expressing a target protein is provided. The method includes the following steps: providing an expression vector, the expression vector including a promoter, a gene encoding a target protein and an FTH1 gene; transfecting the host cells with the expression vector; culturing the host cells in a medium; and adding iron ions to the medium, and screening the surviving host cells to obtain the host cells expressing the target protein. An expression vector and a method for establishing a cell line stably expressing an exogenous recombinant gene are also provided.

Methods for screening host cells expressing target proteins

Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

Anti-TIGIT antibodies and methods of use

The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract ofor an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract ofor an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

Pharmaceutical compositions and method for inhibiting angiogenesis

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Zhubei, Taiwan

Mei-Wei Lin