National University of Singapore

Mei-Wang Casey

Mei Lin Go

Patrick J Casey

Tianming Yang

Jo Lene Leow

Pondy Murugappan Ramanujulu

Kumar Gorla Suresh

The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CHNRRwherein Ris H or C1 to C3 alkyl, Rbeing optionally substituted with &#x2014;OH, &#x2014;SH, &#x2014;NHor NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and Ris C1 to C3 alkyl or (CH)bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group.

ICMT inhibitors

The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same.

Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity

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Singapore, Singapore

Mei-Wang Casey