National Research Council of Canada

Interface Biologics, Inc.

Mei Li

J Paul Santerre

Jianfu Ding

Ming Zhou

Futian Liu

Mike Day

Pascal Vuillaume

Frank J Laronde

A pharmaceutically-active polymeric compound of the general formula (I),Y-[Y-LINK B-X]-LINK B&#x2003;&#x2003;(I)wherein (i) X is a coupled biological coupling agent of the general formula (II)Bio-LINK A-Bio&#x2003;&#x2003;(II)wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of &#x3c;2000 theoretical molecular weight linked to each of said Bio fragments;(ii) Y is LINK B-OLIGO; wherein

Polymeric coupling agents and pharmaceutically-active polymers made therefrom

A process for preparing a fluorinated poly(arylene ether) comprising the repeating unit: wherein n provides a molecular weight up to about 30,000 to 100,000, X represents one of following groups: none, ketone, sulfone, sulfide, ether, hexafluoroisopropylidene, &#x3b1;&#x3c9;-perfluoroalkylene, oxadiazole, and Y is 4,4'-(hexafluoroisopropylidene)-diphenyl, 4,4&#x2032;-isopropylidene diphenyl, 3,3&#x2032;-isopropylidene diphenyl, phenyl, or chlorinated phenol which process comprises reacting a bis(pentafluorophenyl) compound and a bisphenol or hydroquinone in the presence of a dehydrating agent and a polar aprotic solvent is disclosed. Polymers resulting from the process show good promise as new passive optic polymer waveguide materials.

Techniques for the preparation of highly fluorinated polyethers

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Toronto, Canada

Mei Li