Tsinghua University

National Health Research Institutes

Mei-Hui Shih

Chung-Shi Yang

Fong-In Chou

Jen-Kun Chen

Jinn-Jer Peir

Mei-Ya Wang

Chih-Hui Liu

Mo-Hsiung Yang

Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed.

Radioactive gold nanoparticles and methods of making and using them

Growing community of inventors

Taichung, Taiwan

Mei-Hui Shih