Promega Corporation

Life Technologies Corporation

Mei Cong

Brock Binkowski

Matthew B Robers

Mark McDougall

Chad Zimprich

Cesear Corona

Natasha Karassina

Thomas Livelli

Zhong Zhong

Mark Federici

Zhijie Jey Cheng

Brock F Binkowski

Mark G Mcdougall

Jamison Grailer

Provided herein are compositions and methods for monitoring the movement of analytes and/or cellular components across biological membranes (e.g., cell surface internalization). In particular, reporter constructs are provided, the transmembrane movement of which (e.g., by endocytosis) is monitored by methods described herein.

Compositions and methods for monitoring transmembrane trafficking

Provided herein are fluorescent sensor agents, and methods of use and manufacture thereof. In particular, sensor agents are provided that exhibit a detectable change in fluorescence (e.g., fluorescence intensity) upon alteration of the pH of the surrounding environment (e.g., upon moving from one pH environment to another).

pH sensors

Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.

Method for using division arrested cells in screening assays

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Madison, WI, United States of America

Mei Cong