Glyconex, Inc.

Mei-Chun Yang

Tong-Hsuan Chang

Jerry Ting

Shu-Yen Chang

Yu-Yu Lin

Liahng-Yirn Liu

Yen-Ying Chen

Shu-Lun Tang

Sen-itiroh Hakomori

Kazuko Handa

Tsai-Hsia Hong

Ying-Jin Chen

Jaw-Yuan Wen

Liahng-Yim Liu

Ying-Zin Chen

Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.

Therapeutic antibodies

Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.

Anti-extended type I glycosphingolipid antibody, derivatives thereof and use

Growing community of inventors

Taipei, Taiwan

Mei-Chun Yang