Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Patheon Austria Gmbh & Co. Kg

Mehul Thathagar

Peter Poechlauer

Sascha Braune

Stefan Steinhofer

Rafael Wilhelmus E G Reintjens

Nicole Theodora W Linssen

Rafael Wilhelmus Elisabeth Ghislain Reintjens

Michel Goldbach

Nicole Theodora Wilhelmina Linssen

The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a plurality of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm. A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.

Oscillating flow minireactor

A process for the continuous production of a compound of Formula (II), HO&#x2014;R&#x2014;ONO(II) wherein Ris a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO&#x2014;R&#x2014;OH (I) wherein Ris as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime

A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CRR, in a reaction vessel, optionally in the presence of a solvent, wherein, Rand Rare each independently hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, &#x2014;C(O)Ror &#x2014;NR; R, R, Rand Rare each independently hydrogen, C-Calkyl, C-Calkoxy, C-Calkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, &#x2014;C(O)R, &#x2014;NR, &#x2014;SR, &#x2014;S(O)R, or &#x2014;SOR, or Rand Rare as defined above and Rand Rtogether form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, aryloxy, heteroaryl or &#x2014;NR; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, aryloxy or heteroaryl; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process. 

Process for the production of cyclopropane derivatives

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Geleen, Netherlands

Mehul Thathagar